1-boc Piperazine

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1-boc Piperazine

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lifechampharma566
Guest
Jun 24, 2025
10:28 PM

Introduction

1-Boc Piperazine

is a widely used chemical intermediate in pharmaceutical research, known for its role in the synthesis of a wide variety of bioactive molecules. The compound features a piperazine ring protected by a Boc (tert-butoxycarbonyl) group, which enhances its stability and selectivity in multi-step synthetic procedures.

Chemical Identity
IUPAC Name: 1-(tert-Butoxycarbonyl)piperazine

CAS Number: 57260-71-6

Molecular Formula: C9H18N2O2

Molecular Weight: 186.25 g/mol

Appearance: White to off-white crystalline powder

Solubility: Soluble in common organic solvents such as dichloromethane, methanol, and acetonitrile

Structural Features
1-Boc Piperazine consists of a six-membered piperazine ring, where one nitrogen is protected with a tert-butoxycarbonyl (Boc) group. This protection:

Enhances the selective functionalization of the second nitrogen

Provides stability under basic conditions

Is easily removed under acidic conditions, making it ideal for stepwise synthesis

Applications of 1-Boc Piperazine
1. Pharmaceutical Intermediate
It is a key building block in the synthesis of several classes of drugs, including:

Antipsychotics

Antidepressants

Anti-inflammatory agents

Anti-cancer compounds

The Boc group allows for temporary protection during multi-step synthesis, enabling the development of diverse heterocyclic scaffolds.

2. Medicinal Chemistry and Drug Discovery
1-Boc Piperazine is commonly used in combinatorial chemistry and lead optimization, offering:

Increased lipophilicity

Improved pharmacokinetic properties

Potential for receptor binding enhancement

3. Custom Peptidomimetic Synthesis
In the design of peptidomimetics, 1-Boc Piperazine serves as a flexible spacer or scaffold that mimics peptide bonds, useful in:

Enzyme inhibitors

Signal transduction mimics

Receptor ligands

Handling and Safety
Hazards: May cause skin or eye irritation

Precautions: Handle with gloves and eye protection; avoid inhalation or prolonged exposure

Storage Conditions: Store in a tightly sealed container, in a cool, dry place away from acids

Packaging and Supply
Available in:

Small Packs: 5g, 25g, 100g for research use

Bulk Quantities: 1kg, 5kg, and custom volumes for commercial production

Supplied with COA, MSDS, and global shipping options.

Conclusion
1-Boc Piperazine is a cornerstone intermediate in the field of organic and medicinal chemistry. Its versatility, ease of use, and clean deprotection make it a preferred choice for researchers and manufacturers developing advanced drug candidates and custom molecules.

Need bulk or custom-packed 1-Boc Piperazine? Contact us for quotations, technical documentation, and application support tailored to your R&D or production goals.

scromiting
Guest
Jun 24, 2025
11:00 PM

Scromiting is a slang term combining “screaming” and “vomiting,” used to describe a scromiting severe reaction sometimes seen in individuals who chronically use high-potency cannabis. This condition, medically known as Cannabinoid Hyperemesis Syndrome (CHS), leads to intense nausea, uncontrollable vomiting, and abdominal pain. During episodes, sufferers may scream due to the extreme discomfort, hence the term. It often develops after long-term, heavy marijuana use, and symptoms are temporarily relieved by hot showers.

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